Cindy Hyde-Smith to face DA Scott Colom in battle for Mississippi Senate seat

The race for the Mississippi Senate seat will be held in November and will see a onetime incumbent square off against a foe whose judicial appointment he once blocked throughout his life.

Sen. Cindy Hyde-Smith, R-Miss., cruised to victory in the primary to win the GOP nomination for Senate in Mississippi. She defeated political newcomer Sarah Adlakha, who had challenged Hyde-Smith’s influence in Washington, D.C. since her appointment in 2018.

Hyde-Smith is running for a second term in the upper chamber and is expected to continue her tenure in the GOP’s widening fight to maintain control of the Senate in deep-red Mississippi.

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But he will face a Democratic opponent he has dealt with before; But the election is not on the battlefield.

Mississippi District Attorney Scott Colom rose to the top of a crowded primary to win the Democratic nomination for Magnolia State Senate. He took down U.S. Marine Corps veteran Albert Littell and Priscilla Till, cousin of Emmett Till, who was kidnapped and lynched in Mississippi in the 1950s.

Hyde-Smith and Colom have a history dating back to the Biden administration, when they blocked the lawmaker’s nomination to serve as a district court judge in Mississippi.

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At the time, he used the veto power every state senator had, known as a blue shift in the upper chamber, to weigh in on his judicial nominee; It was a tradition that President Donald Trump has demanded be eliminated to nullify Democratic resistance to his own judicial nominees.

District Attorney Scott Colom in Columbus, Miss., on Monday, Aug. 18, 2025. (Scott Colom (Christopher Dilts) for the Senate)

Hyde-Smith told the Magnolia Tribune at the time that while she acknowledged Colom was “smart and well-liked in her district,” she had concerns about his record.

“Colom has never seen a Biden/Harris policy he didn’t like,” Nathan Calvert, a spokesman for the Hyde-Smith campaign, told Fox News Digital.

“Senator Hyde-Smith is proud to oppose the judicial nomination of far-left extremists who support a radical transgender agenda,” Calvert said. “He opposes men participating in women’s sports and believes we need judges who will take the same stance.”

“Senator Hyde-Smith believes we must cut government spending, combat inflation (caused by excessive government spending), and reduce (not increase) our mounting national debt, and will continue to vote to do so,” he continued.

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Sunrise light hits the U.S. Capitol dome on January 2, 2025. (Bill Clark/CQ-Roll Call, Inc. via Getty Images)

“As someone with a strong interest in protecting the rights of girls and women, I am concerned that Scott Colom opposes legislation to protect female athletes,” Hyde-Smith said. “The significant support his campaign has received from George Soros also weighs heavily against his candidacy. In my view, I simply cannot support his nomination to serve a life term on the federal bench in Mississippi.”

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Colom, meanwhile, went after Hyde-Smith, who voted against federal funds coming to Mississippi, which is consistently ranked as the poorest state in the country.

The website accused Hyde-Smith of “no longer working for us, voting against jobs and investments in Mississippi because it serves the agenda of her donors.”

Fox News Digital reached out for comment on Colom’s campaign but did not immediately hear back.