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Blood test may tell when Alzheimer’s symptoms are forming

(NewsNation) — A new blood test can tell individuals if: Alzheimer’s disease According to research, the symptoms are imminent.

Study, funded A study by the National Institutes of Health found that certain circular RNAs, or circRNAs, can strongly indicate whether symptoms are coming. Specific RNAs in the blood nearly triple patients’ risk of developing symptoms, researchers say.

Director of the NIH National Institute on Aging, Dr. “In a clinical setting, being able to identify patients on the verge of symptom onset would be invaluable,” said Richard Hodes. “Having this information can help us select the right patients for clinical trials and better determine which treatments are effective in preventing cognitive decline.

Researchers analyzed blood data from more than 1,200 participants from several independent groups and discovered a set of 34 circRNAs linked to the disease. They noted that predictive models for the circRNA set identified individuals with the pathology of the disease in the same way as models trained on protein pTau217 data.

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Data for protein pTau217 is the leading clinical blood-based biomarker for Alzheimer’s.

Dr. Carlos Cruchaga added: “Patients treated with new Aβ-removing therapies may be pTau negative but still have Alzheimer’s disease.” “These circular RNAs can give us a more complete view of someone’s overall disease biology.”

Current blood tests for Alzheimer’s offer stable diagnoses by detecting signs of amyloid plaques, which resemble clumps of sticky protein that slowly accumulate in the brain.

A previous study by Cruchaga et al revealed that circRNAs in the brain are linked to dementia and neuropathological severity.

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