Common over-the-counter medication slashes colorectal cancer recurrence in half

A common drug over the counter can significantly reduce the risk of colorectal cancer.

In a Swedish study, it has been shown to reduce half for patients with a low dose of aspirin, tumors with a specific genetic mutation and rectal cancer.

According to a press release, researchers at Karolinska Institutet and Karolinska University Hospital followed more than 3,500 cancer patients from 33 hospitals in Sweden, Norway, Denmark and Finland. All patients were operated to remove their tumors.

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Among those with a certain gene mutation on the PIK3 signal path, half of them took 160 milligrams of aspirin a day and the other half placebo.

After a three -year period, the risk of cancer recurrence in aspirin areas compared to the placebo group decreased by 55%.

“Alascca shows that low -dose aspirin somatic PI3K road changes significantly reduce recurrence in patients with colorectal cancer patients.” Work writer Anna Martling, MD, PH.D., Professor Karolinska University Institutetute and Senior Consulting Digital.

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“This applies to more than one -third of all patients with seiser colorectal cancer.”

According to Martling, women who required more investigations were stronger.

The findings were published in the New England Medical Magazine.

Martling is a global and extremely cheap medicine compared to many modern cancer drugs.

Aspirin, which aims to alleviate pain, fever and inflammation, is a non-steroidal anti-inflammatory drug (NSAID). Low doses of drugs are used to prevent blood clots.

This study confirms that previously observational studies proposed in a randomized study.

FOX News Senior Medical Analyst Marc Siegel did not participate in the study, but in an interview with Fox News Digital, he shared his reaction.

“Aspirin is an anti-inflammatory and is about reducing growth factors,” he said. “Numerous studies have shown that regular use of NSAIDs reduces the risk of developing and dying from colon cancer.”

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Siegel said that the PIK3CA mutation in the study leads to rapid cell growth in cancers in 55% of breast cancers and about 30% of colon cancers.

“This great, randomized Scandinavian work, colon cancer and PIK3 mutations in those with more than 50% reduction.”

The author had some restrictions on the study. “There are warnings as in any experiment. The study was not strengthened for detailed sub -group analyzes and patients older than 80 were not included.” He said.

“Longer follow -up is also required to verify the effects on general survival.”

According to the researchers, some common side effects of Aspirin include stomach problems and increased bleeding tendency. Stomach ulcer should not be used by people with bleeding disorder or asthma.

Experts, other blood examined agents or alcohol users should use aspirin carefully, he said.

Despite restrictions, researchers believe that the results are “immediately relevant” for clinicians and guide committees.

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“PI3K road changes test should be taken into consideration in colorectal cancer patients after surgery.” “For patients, however, it is important to know that aspirin is not recommended outside a medical context until guidance and treatment of physicians adopt these findings.”

According to the researcher, the trial is a powerful example of “sensitive medicine” and is a strong example of high -tech platforms that meet a well -known, low -cost drug.

“In general, the regime can prevent thousands of recurrences and save lives every year, especially in environments where access to expensive new drugs are limited.”

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When everyone who has colon cancer will be given regular aspirin, Siegel said that this should be used more widely than before, but doctors should analyze the risks and benefits of aspirin use according to the situation.

The study was partly financed by the Swedish Research Council and the Swedish Cancer Association.