India discovers world’s rarest blood group ‘CRIB’ in Bengaluru woman: What it is and why it’s so unique
In an international case, a 38 -year -old woman from Koular near Bengaluru found that she had a previously known blood group, which is now officially known as a cradle. Experts believe that there may be the most rare blood group discovered so far, it is known that only one approved individual has.
The new Blood Group was called Crib, Crib:
CR, which represents Cromer, is classified under the blood group system
IB, India, where discovery is made, standing for Bengaluru
He is the only person in the world known to have this blood group.
What are five blood groups?
The Beşik Blood Group is a newly discovered and extremely rare blood group that is widely known as ABO and RH systems. While the cradle means “chromosome zone defined as a blood group”, the abbreviation is symbolic due to its potential effect on neonatal and fetal medicine. This blood group is classified under the Inra (Indian Rare antigen) system officially recognized by the International Blood Transfusion (ISBT). Since people with this blood group lack this antigen, blood transfusion becomes extremely difficult, because only the cradle is negative blood-compatible-makes the donors extremely rare.
Why was his blood so unique?
Bangalore, Old Airport Road, Manipal Hospital Consultant and Transfer Medicine President Dr. C. Shivaram explains the uniqueness of the case. Although most people are familiar with ABO and RH blood group systems, there are actually 47 international blood groups, each defined by certain antigens.
In the case of this woman, the blood exhibited panreactivity – a critical warning sign that shows incompatibility with all known donor samples. Even after testing 20 family members, there was no match that caused researchers to suspect a completely unknown blood group.
The root cause revealed that the Cromer blood group system, which is associated with glycoproteins in the red blood cell membranes, was an unidentified antigen. Until this discovery, no variant like Crib was documented.
What is the Cromer System and why is it so rare?
While the Cromer Blood Group system consists of several antigens, some of which are common in most people, others are extremely rare. Typically, individuals develop antibodies against these rare antigens because of the following factors:
- Pregnancy
- Previous Blood Transfusions
- Genetic mutations
In this special case, the woman had never received any transfusion before. Nevertheless, red blood cells responded as if each donor blood unit was foreign and incompatible.
This unusual reaction proposed the existence of an unknown antigen – that no blood bank existing can match. The situation was so complex that doctors made a rare decision to perform their surgery without transfusion-a highly risky movement managed to doubtfully.
