Study recommends two half-dose combination of drugs in a single pill for good blood pressure control in Indians

In order to guide optimal combination hypertension therapy in South Asian patients, a recent study has been proposed to half a dose of two drugs in a single pill combination from the beginning of hypertension treatment.

Paper, ‘Comparison of bilateral treatments for hypertension treatment in IndiaPublished in the magazine Nature MedicalIn a multi -centered trial in 32 regions in India, he investigated the blood pressure (BP) of the three antihypertensive combination (BP), which was widely recommended in a single pill. Approximately 2,000 adults with uncontrolled or untreated hypertension were examined and interventions contained three single volume pairs: amlodipine + perindopril, peridopril + indapamide and amlodipine + indapamide.

Researchers, in patients aged 30-79 years, 30-79 years of age, equivalent BP discounts and similar BP control rates, he said. With high tolerableness for six months, all combinations are equally safe and effective.

Yeni Delhi said, “It should not be forgotten that we do not propose a very irrelevant regime. It should not be forgotten that we do not propose multiple medicine regime. It should be noted that we do not recommend multiple medicine regime. Multiple medicine regime should be recommended. Polypharma will only lead to the discontinuation of treatment. “What we recommend is to start with a half dose of two drugs in a single pill combination. If BP control does not occur, it is important to titre to full doses. However, if BP continues to be higher than 140/90, additional medications will be added,” he explains.

“So far it is surprising that we are based on the treatment of Western manuals so far,” Prabhakaran adds. This study tests global guidelines for the treatment of hypertension among patients in India, because these combinations are already present here. These drugs operate on multiple paths and are synergistic with low side effects.

“Many doctors, even cardiologists think that they should start with a low dose and continue to rise later, Chennai says. “Even patients are reluctant to start drugs, but these combinations we have tested are really effective in reducing BP and the side effects are small,” he adds. Side effects observed during the trial include cough, foot swelling and low potassium in some sub -groups and are not statistically significant.

Prabhakaran said, “The biggest problem in India is only 20% of hypertension. Only 20% of individuals with hypertension are treated to target urban areas and a decrease of 10 mm in BP in rural areas can prevent 40% of these single -sketches, and this is a need to provide a pharmaceutical industry. It creates a pharmaceutical industry.