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Universal framework enables custom 3D point spread functions for advanced imaging

The artistic depiction of spatial and spectral engineering of 3D point spread functions using rural optical processors. Credit: Ozcan Lab / UCLA

Engineers at the UCLA Samueli Engineering School offered a universal framework for the Point Breeding Function (PSF) engineering, which provides synthesis of arbitrary, spatially changing 3D PSFs using difactive optical processors. Research published in the journal Light: Science and Applications.

This frame allows advanced imaging properties such as 3D multispectral imaging, without the need for spectral filters, axial scanning or digital reconstruction.

PSF engineering plays an important role in modern microscopy, spectroscopy and computational imaging. Traditional techniques typically use phase masks that restrict the complexity and mathematical representation of accessible PSF structures.

The approach developed in UCLA enables 3D PSF engineering, which is optimized by using deep learning algorithms and is a physical fragile optical processor, and the arbitrary, spatially changing 3D PSF engineering.

Through comprehensive analyzes, researchers have shown that these fragile processors could approach the linear transformation between the 3D optical density distributions in input and output volumes. This provides the limited limited control of the three -dimensional light, by opening the path of highly customized and sophisticated optical functions for 3D optical information processing.

By jointly engineering the spatial and spectral properties of 3D PSFs, it supports strong imaging methods such as 3D Multispectral imaging without frame, mechanical scanning, spectral filters or post -calculation processes. This completely optical approach offers unique versatility for high -speed, high efficiency optical systems.

This study indicates a significant stepstone for future progress in calculation imaging, optical detection and spectroscopy, as well as processing 3D optical information. Potential applications include compact multispectral images, high efficiency 3D microscopy platforms and new optical data coding and transmission systems.

Study MD Sadman Sakib Rahman and Dr. It was carried out by Aydogan Ozcan by UCLA Electrical and Computer Engineering Department and California Nanostems Institute (CNSI).

More information:
MD Sadman Sakib Rahman et al. Light: Science and Applications (2025). Doi: 10.1038/s41377-025-01887-x

UCLA Engineering Technology Development Institute


Reference: Universal Framework provides special 3D point spread functions for advanced imaging (2025, 15 June) dated 16 June 2025.

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