Scientists create ‘virus cocktail’ to fight superbugs
Scientists have developed what they call “virus cocktail” to fight super insects in a major progress for the treatment of infectious disease.
Monash University and Alfred, researchers in Melbourne, Australia, developed a product that uses bacterial viruses known as ‘bacteriophages’ to combat antimicrobial resistant bacteria.
The treatment called Entelli-02 is a five-sided cocktail designed to target the Enterobacter Cloacae complex (ECC), a group of bacteria responsible for severe, less curable infections.
“We designed and developed a clinical ready -made faa therapy product in a local hospital, adapted to an amr bacterial pathogen,” he said. Nature Microbiology.
“Entell-02 is not only a scientific success, but a clinical tool for the use of facades against bacterial pathogens with a deadly, drug resistant.”
Enterobacter infections are very difficult to treat and in 2019 globally is linked to more than 200,000 deaths.
They emerged in hospitals around the world and have the capacity to develop resistance to most of the latest -row antibiotics.
“Antibiotic resistance is one of the biggest challenges of modern medicine, Prof said Professor Barr. “With Entelli-02, we show that wave therapy can be precise, strong and ready for clinical distribution.”
Using a ten-year bacterial isolate, Dr. Dinesh Subisedi said that the research team developed and produced the Entelli-02 with a meticulous faajasy, genetic and pre-clinical test process.
Dr We started with three fashes in our cocktail at the beginning, but through repeated design, we developed a cocktail by genetically adapting viruses to expand the host intervals, and then we selected two additional wajs with improved treatment results, ”he said.
“The final product Entell-02 contains five wajs that can reduce bacteria loads over 99 percent in infected mice that can kill a wide range of enterobacter insulation.”
The team is now ready with a “ready -made product” to support the treatment of some of the most difficult infections.
According to a recent report of Disease Control and Prevention Centers (CDC) scientists, infection rates from drug-resistant “nightmare bacteria” increased almost 70 percent between 2019-2023.
Bacteria, which are difficult to treat because of a specific gene, continued to increase, and CDC researchers wrote in an article published last Monday. Internal Medicine Annals.
Researchers said that only two antibiotics work against these infections and that drugs are expensive and should be applied through an IV.
The so -called NDM gene, the bacteria were once considered exotic and were bound to a small number of patients with medical care abroad. Although researchers and numbers are still small, the proportion of US cases has increased more than five times in recent years.
“The rise of NDMs in the USA is a serious danger and very worrying,” he said, “
CDC scientists are unrecognizable carriers of many people’s drug -resistant bacteria.
